Developing an olfactory cell therapy for spinal cord injury

a) Vertebral Column

b) The Vertebra

c) Meninges

d) Spinal Cord

e) Spinal Nerves

a) Vertebral Column

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•The vertebral column or the backbone is a stack like arrangement of small bony blocks known as the vertebrae. 

•There are a total of 33 vertebrae:

     •7 in the neck (cervical vertebrae)

     •12 in the upper back (thoracic vertebrae)

     •5 in the lower back (lumbar vertebrae)

     •5 in the hip area (fused into a single sacrum)

     •4 in the tailbone (fused to form a single coccyx)

•Every individual vertebra is separated from the next vertebra by a soft cushion like disc of cartilage called an intervertebral disc. 

•Since the sacrum and coccyx are fused, the vertebrae in those are not separated by the intervertebral discs.

•Spinal nerves emerge from the spinal column from gaps between the vertebrae

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A side view of the spinal column

The spinal column is made up of separate bones each known as a vertebra (plural: vertebrae) and between each vertebra is an intervertebral disc that connects each bone, allows slight movement of the bones and acts as a shock absorber for the spine.

B) The Vertebra

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A Typical Vertebra

•The sketches here show a typical vertebra

•The vertebral body and laminae form the vertebral foramen, and the vertebral foramen of all the vertebrae form a long vertebral canal that contains the spinal cord

•Cervical vertebrae are smaller and flatter compared to others

•Thoracic vertebrae are larger than the cervical ones and they provide attachment to the rib cage

•Lumbar vertebrae are the largest and thickest

C) Meninges

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A cross-section of the vertebra and spinal cavity containing the spinal cord.

•The brain and spinal cord have 3 layers of wrappings called meninges:

    1. Dura mater (outer) latin: 'tough mother'

    2. Arachnoid mater (middle) latin: 'spider mother'

    3. Pia mater (inner) latin: 'gentle mother'

•The dura mater is the outermost layer and the strongest layer. The space between the dura mater and the vertebrae is known as epidural space.

•The middle layer is called arachnoid layer because it has a web-like network of blood vessels that produces the cerebrospinal fluid (CSF)  

•Pia mater is the innermost layer which is tightly attached to the tissue of brain and spinal cord like a transparent, laminating membrane.

•Together all three layers of meninges protect the CNS from any harm.

D) spinal cord

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  • The spinal cord is a long and slender bundle of nerve fibres that connects the brain to the rest of the body
  • It is about 45-50 centimetres long and extends from the first cervical vertebra till the lower border of first lumbar vertebra or the upper border of the second.
  • The lower end tapers into a conical shape known as conus medularis.
  • The tip of the conus is anchored to the coccyx via a filament known as filum terminale.
  • The cord is shorter than the vertebral column and therefore, the spinal segments and vertebral levels do not correspond with each other.
  • The spinal cord gives off 31 pairs of spinal nerves, one pair from each segment:
  •      8 cervical, 12 thoracic, 5 lumbar, 3 sacral and 1 coccygeal.


  

  • The spinal cord is divided into grey matter and white matter on the inside.
  • The core of the cord contains grey matter that looks like the letter ‘H’.
  • Grey matter contains the cell bodies of neurons that give rise to spinal nerves.

  

  • The white matter surrounds the grey matter and forms the peripheral part of the cord. It appears white because it contains myelinated axon fibres in bundles travelling up and down the spinal cord.
  • These bundles are called spinal tracts. Tracts going up to the brain are called sensory or ascending tracts. These tracts carry all kinds of sensations from the body, to the brain
  • The tracts that travel from brain to the rest of body are known as motor or descending tracts. They carry commands issued from the brain to control all voluntary and non voluntary movements of the body.

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Spinal Cord Cross Section

In a cross-section of the spinal cord you can see the grey and white matter. White matter is white due to the fatty sheaths that are found around the axons of the neuronal cell axon. These are known as myelin sheaths. Grey matter axons do not have myelin sheaths.

E) Spinal Nerves

•As described before,  31 pairs of spinal nerves emerge from the spinal cord:

     •8 cervical, 12 thoracic, 5 lumbar, 3 sacral and 1 coccygeal

•Each spinal segment gives off a nerve root from the front- the ventral root and a root from the back- the dorsal root on both sides. The ventral and dorsal root from each side come together and join each other to form one spinal nerve.

•This way, each spinal segment gives off one pair of spinal nerves, one on each side. Each spinal nerve carries motor fibres from the ventral root sensory fibres to the dorsal root.

•Other than this, spinal nerves from cervical, thoracic and lumbar segments also carry sympathetic nerve fibres that control the autonomic (involuntary) actions.

•Each spinal nerve supplies specific region of the body and specific organs and muscles. The details of this functional distribution is in module 4.